Current Issue : July-September Volume : 2017 Issue Number : 3 Articles : 2 Articles
Phenolics are the large classes of compounds, spread extensively in plant kingdom, especially the secondary metabolites like simple phenol and phenolic acids. Article was designed to explore the therapeutic effect of quinic acid through available literature (last 20 years literature). The last 20 years literatures was carried out by searching bibliographic data bases such as Pubmed, Scopus, Google scholar and web of science. The data were collected by keywords like “Quinic Acid” and “Pharmacological activity” without narrowing or limiting search items. Publications with abstracts were reviewed only. Total publications found in initial research were 80, in which 37 publications were considered for study and remaining were excluded because of its specificity to the subject. This article will provide all the information of quinic acid like description, physical properties, pharmacokinetics and pharmacodynamics studies, molecular mechanism and its scope for future work....
The ryanodine receptors (RyR) are located in the sarcoplasmic reticulum (SR). Generally contraction of skeletal muscle is caused by the release of calcium ions from the sarcoplasmic reticulum (SR) after the depolarization of transverse tubules. This ryanodine acts as a junctional gap between the SR and the transverse tubule and it acts as a key for calcium release channel during the process of excitation-contraction (E-C) coupling. In general, Ca2+ influx or depolarization will activate the RyR channels, but the specific mechanisms involved in deactivation or turn off the RyR channels unclear. They are three distinct subtypes of the ryanodine receptor in mammalian tissues, namely skeletal muscle, cardiac muscle and in brain. A novelty has been explained stating that nicotine acts on ryandine receptors but not on nicotinic receptors. Here in this paper a general overview on ryanodine receptors is explained....
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